Evaluation of Anticonvulsant Activity of Dual COX-2/5-LOX Inhibitor Darbufelon and Its Novel Analogues

Neuroinflammation is an integral part of epilepsy pathogenesis and other convulsive conditions, non-steroidal anti-inflammatory drugs (NSAIDs) present a potent tool for the contemporary search design novel anticonvulsants. In paper, evaluation anticonvulsant activity potential NSAID dual COX-2/5-LOX inhibitor darbufelone methanesulfonate using scPTZ model in mice dose 100 mg/kg reported. Darbufelone possesses properties presents interest in-depth studies as possible multi-target agent with activity. The series 4-thiazolidinone derivatives have been synthesized following analogue-based drug hybrid-pharmacophore approach matrix. showed significant protection level animals are promising compounds anticonvulsants satisfactory drug-like parameters.